Drug interactions
Cyproheptadine + Lurasidone
Severity: Moderate
Cyproheptadine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, so combined use may add to sedation and impaired alertness. Cyproheptadine's serotonin antagonism might also modify lurasidone's receptor effects, though clinical significance is unclear.
What this interaction means in plain words
Cyproheptadine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects from H1 antagonism and antipsychotic activity.
What to do
Monitor for excess drowsiness and psychomotor impairment, and counsel on driving. Consider a non-sedating antihistamine if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Lurasidone?
MediHelp rates the interaction as moderate. Cyproheptadine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, so combined use may add to sedation and impaired alertness. Cyproheptadine's serotonin antagonism might also modify lurasidone's receptor effects, though clinical significance is unclear.
How serious is the interaction between Cyproheptadine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and psychomotor impairment, and counsel on driving. Consider a non-sedating antihistamine if sedation is problematic.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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