Drug interactions
Cyproheptadine + Nabilone
Severity: Moderate
Cyproheptadine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause drowsiness and dizziness, and nabilone can also cause cognitive effects and tachycardia. Combined use may increase sedation and impair judgment and coordination.
What this interaction means in plain words
Cyproheptadine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive sedation and confusion, and advise against driving or operating machinery. Reduce doses if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Nabilone
Frequently asked questions
Can I take Cyproheptadine with Nabilone?
MediHelp rates the interaction as moderate. Cyproheptadine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause drowsiness and dizziness, and nabilone can also cause cognitive effects and tachycardia. Combined use may increase sedation and impair judgment and coordination.
How serious is the interaction between Cyproheptadine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and confusion, and advise against driving or operating machinery. Reduce doses if impairment develops.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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