Drug interactions
Cyproheptadine + Paliperidone
Severity: Moderate
Cyproheptadine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and together they may increase sedation and orthostatic dizziness. Cyproheptadine's anticholinergic activity adds modestly to the burden in older patients.
What this interaction means in plain words
Cyproheptadine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and H1 and alpha-adrenergic related effects.
What to do
Monitor sedation and blood pressure on standing, and advise caution when driving. Reduce doses if symptoms are bothersome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Cyproheptadine with Paliperidone?
MediHelp rates the interaction as moderate. Cyproheptadine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, and together they may increase sedation and orthostatic dizziness. Cyproheptadine's anticholinergic activity adds modestly to the burden in older patients.
How serious is the interaction between Cyproheptadine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure on standing, and advise caution when driving. Reduce doses if symptoms are bothersome.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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