Drug interactions
Cyproheptadine + Papaverine
Severity: Minor
Cyproheptadine and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine is not a significant sedative, so a meaningful additive sedative effect is not well supported. No clinically important interaction is established.
What this interaction means in plain words
Cyproheptadine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Papaverine belongs to Cardiovascular.
Why it happens
No established mechanism; any additive drowsiness would be minor.
What to do
No specific action is needed beyond monitoring for drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Cyproheptadine with Papaverine?
MediHelp rates the interaction as minor. Cyproheptadine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine is not a significant sedative, so a meaningful additive sedative effect is not well supported. No clinically important interaction is established.
How serious is the interaction between Cyproheptadine and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring for drowsiness.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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