Drug interactions
Cyproheptadine + Pentazocine
Severity: Moderate
Cyproheptadine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a sedating first-generation antihistamine and pentazocine is an opioid agonist-antagonist. Taken together they can produce additive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression.
What this interaction means in plain words
Cyproheptadine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from histamine H1 blockade and opioid receptor activity.
What to do
Start with the lowest effective doses and monitor for excessive sedation and respiratory depression. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Cyproheptadine with Pentazocine?
MediHelp rates the interaction as moderate. Cyproheptadine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine is a sedating first-generation antihistamine and pentazocine is an opioid agonist-antagonist. Taken together they can produce additive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression.
How serious is the interaction between Cyproheptadine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor for excessive sedation and respiratory depression. Advise patients to avoid driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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