Drug interactions
Cyproheptadine + Perphenazine
Severity: Moderate
Cyproheptadine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and each has anticholinergic activity. Combined use may increase drowsiness, dizziness and anticholinergic effects such as dry mouth, constipation and urinary retention, especially in older adults.
What this interaction means in plain words
Cyproheptadine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1 and muscarinic antagonism plus dopamine blockade.
What to do
Monitor for oversedation and anticholinergic toxicity, and reduce doses in older or frail patients. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Cyproheptadine with Perphenazine?
MediHelp rates the interaction as moderate. Cyproheptadine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and each has anticholinergic activity. Combined use may increase drowsiness, dizziness and anticholinergic effects such as dry mouth, constipation and urinary retention, especially in older adults.
How serious is the interaction between Cyproheptadine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, and reduce doses in older or frail patients. Counsel patients to avoid driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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