Drug interactions
Cyproheptadine + Tapentadol
Severity: Moderate
Cyproheptadine and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tapentadol is an opioid and cyproheptadine is a sedating antihistamine. Together they can cause additive drowsiness, dizziness and respiratory depression.
What this interaction means in plain words
Cyproheptadine and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from H1 antagonism and mu-opioid agonism.
What to do
Use the lowest effective doses and monitor for sedation and slowed breathing. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Tapentadol?
MediHelp rates the interaction as moderate. Cyproheptadine and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tapentadol is an opioid and cyproheptadine is a sedating antihistamine. Together they can cause additive drowsiness, dizziness and respiratory depression.
How serious is the interaction between Cyproheptadine and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and slowed breathing. Counsel patients to avoid alcohol and driving.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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