Drug interactions
Cyproheptadine + Ziconotide
Severity: Moderate
Cyproheptadine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intrathecal ziconotide commonly causes dizziness, confusion and reduced alertness, and cyproheptadine adds sedation. Combined use can worsen cognitive impairment and drowsiness.
What this interaction means in plain words
Cyproheptadine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; ziconotide blocks N-type calcium channels while cyproheptadine blocks H1 receptors.
What to do
Monitor for sedation and changes in cognition or mental status, and lower the dose of the oral sedative if impairment develops. If severe cognitive symptoms occur, reduce or stop ziconotide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Cyproheptadine with Ziconotide?
MediHelp rates the interaction as moderate. Cyproheptadine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intrathecal ziconotide commonly causes dizziness, confusion and reduced alertness, and cyproheptadine adds sedation. Combined use can worsen cognitive impairment and drowsiness.
How serious is the interaction between Cyproheptadine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and changes in cognition or mental status, and lower the dose of the oral sedative if impairment develops. If severe cognitive symptoms occur, reduce or stop ziconotide.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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