Drug interactions
Cyproheptadine + Zolmitriptan
Severity: Minor
Cyproheptadine and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine blocks serotonin 5-HT2 receptors and may blunt the therapeutic effect of serotonin receptor agonists. Zolmitriptan may therefore give less relief of migraine in patients taking cyproheptadine.
What this interaction means in plain words
Cyproheptadine and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Zolmitriptan belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of serotonin receptor activity by cyproheptadine, a serotonin antagonist.
What to do
Assess migraine response to zolmitriptan; if relief is inadequate, consider whether cyproheptadine is needed or choose another acute migraine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Zolmitriptan?
MediHelp rates the interaction as minor. Cyproheptadine and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyproheptadine blocks serotonin 5-HT2 receptors and may blunt the therapeutic effect of serotonin receptor agonists. Zolmitriptan may therefore give less relief of migraine in patients taking cyproheptadine.
How serious is the interaction between Cyproheptadine and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess migraine response to zolmitriptan; if relief is inadequate, consider whether cyproheptadine is needed or choose another acute migraine therapy.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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