Drug interactions
Dabigatran + Melatonin
Severity: Minor
Dabigatran and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin may have slight effects on coagulation, so a theoretical additive bleeding tendency exists with dabigatran. No convincing clinical evidence of a meaningful interaction exists.
What this interaction means in plain words
Dabigatran and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak effect on hemostasis; the mechanism is not established.
What to do
No dose change is needed; counsel the patient to report bleeding or bruising.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Dabigatran with Melatonin?
MediHelp rates the interaction as minor. Dabigatran and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin may have slight effects on coagulation, so a theoretical additive bleeding tendency exists with dabigatran. No convincing clinical evidence of a meaningful interaction exists.
How serious is the interaction between Dabigatran and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; counsel the patient to report bleeding or bruising.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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