Drug interactions
Dabigatran + Vortioxetine
Severity: Moderate
Dabigatran and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants impair platelet serotonin uptake and aggregation, which increases bleeding risk when combined with anticoagulants. Dabigatran is a direct thrombin inhibitor, so gastrointestinal and other bleeding may be more likely. The effect is a pharmacodynamic add-on rather than a change in drug levels.
What this interaction means in plain words
Dabigatran and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Impaired platelet function from reduced platelet serotonin combined with anticoagulation by thrombin inhibition.
What to do
Monitor for signs of bleeding, particularly gastrointestinal, and review other bleeding risk factors such as NSAIDs. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Dabigatran with Vortioxetine?
MediHelp rates the interaction as moderate. Dabigatran and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonergic antidepressants impair platelet serotonin uptake and aggregation, which increases bleeding risk when combined with anticoagulants. Dabigatran is a direct thrombin inhibitor, so gastrointestinal and other bleeding may be more likely. The effect is a pharmacodynamic add-on rather than a change in drug levels.
How serious is the interaction between Dabigatran and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly gastrointestinal, and review other bleeding risk factors such as NSAIDs. Consider gastroprotection in high-risk patients.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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