Drug interactions
Dabigatran etexilate + Dronedarone
Severity: Major
Dabigatran etexilate and Dronedarone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and raises dabigatran plasma concentrations, increasing the risk of bleeding. The effect is greater in patients with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of dabigatran by dronedarone, increasing absorption and exposure.
What to do
Reduce the dabigatran dose to the labeled lower dose in atrial fibrillation with CrCl 30-50 mL/min, and avoid the combination if CrCl is below 30 mL/min. Monitor renal function and bleeding signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Dronedarone?
MediHelp rates the interaction as major. Dabigatran etexilate and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits P-glycoprotein and raises dabigatran plasma concentrations, increasing the risk of bleeding. The effect is greater in patients with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dabigatran dose to the labeled lower dose in atrial fibrillation with CrCl 30-50 mL/min, and avoid the combination if CrCl is below 30 mL/min. Monitor renal function and bleeding signs.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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