Drug interactions
Dabigatran etexilate + Itraconazole
Severity: Major
Dabigatran etexilate and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits intestinal and renal P-glycoprotein, raising dabigatran exposure and bleeding risk. Dabigatran labeling advises against this combination in patients with significant renal impairment, and in some regions it is contraindicated.
What this interaction means in plain words
Dabigatran etexilate and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
P-glycoprotein inhibition increases dabigatran absorption and reduces its elimination.
What to do
Avoid the combination in moderate to severe renal impairment, and follow local labeling, which may contraindicate it. Otherwise consider dose reduction per labeling and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Itraconazole?
MediHelp rates the interaction as major. Dabigatran etexilate and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole inhibits intestinal and renal P-glycoprotein, raising dabigatran exposure and bleeding risk. Dabigatran labeling advises against this combination in patients with significant renal impairment, and in some regions it is contraindicated.
How serious is the interaction between Dabigatran etexilate and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in moderate to severe renal impairment, and follow local labeling, which may contraindicate it. Otherwise consider dose reduction per labeling and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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