Drug interactions
Dabigatran etexilate + Ivacaftor
Severity: Moderate
Dabigatran etexilate and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a weak P-gp inhibitor and may modestly increase dabigatran exposure. The risk of bleeding is higher in patients with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Ivacaftor belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-gp efflux by ivacaftor increases dabigatran absorption.
What to do
Monitor for signs of bleeding and check renal function; avoid the combination or choose another anticoagulant if creatinine clearance is markedly reduced. Follow dabigatran labeling for P-gp inhibitors in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Dabigatran etexilate with Ivacaftor?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor is a weak P-gp inhibitor and may modestly increase dabigatran exposure. The risk of bleeding is higher in patients with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check renal function; avoid the combination or choose another anticoagulant if creatinine clearance is markedly reduced. Follow dabigatran labeling for P-gp inhibitors in renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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