Drug interactions
Dabigatran etexilate + Lasmiditan
Severity: Moderate
Dabigatran etexilate and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-gp and may increase dabigatran exposure. The effect is likely modest with single, occasional doses of lasmiditan but may increase bleeding risk in renal impairment.
What this interaction means in plain words
Dabigatran etexilate and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-glycoprotein by lasmiditan increases dabigatran absorption.
What to do
Avoid lasmiditan in patients on dabigatran where possible, or monitor for bleeding if used; labeling for lasmiditan advises avoiding concurrent P-gp substrates. Consider a different acute migraine treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Lasmiditan?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-gp and may increase dabigatran exposure. The effect is likely modest with single, occasional doses of lasmiditan but may increase bleeding risk in renal impairment.
How serious is the interaction between Dabigatran etexilate and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lasmiditan in patients on dabigatran where possible, or monitor for bleeding if used; labeling for lasmiditan advises avoiding concurrent P-gp substrates. Consider a different acute migraine treatment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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