Drug interactions
Dabigatran etexilate + Lonafarnib
Severity: Moderate
Dabigatran etexilate and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak inhibitor of P-glycoprotein and may raise dabigatran exposure by reducing its intestinal efflux. Higher dabigatran levels increase the risk of bleeding, particularly in patients with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of dabigatran etexilate increases its absorption.
What to do
Monitor closely for bleeding and check renal function. Consider reducing the dabigatran dose or choosing another anticoagulant if bleeding occurs or renal impairment is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Lonafarnib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a weak inhibitor of P-glycoprotein and may raise dabigatran exposure by reducing its intestinal efflux. Higher dabigatran levels increase the risk of bleeding, particularly in patients with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and check renal function. Consider reducing the dabigatran dose or choosing another anticoagulant if bleeding occurs or renal impairment is present.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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