Drug interactions
Dabigatran etexilate + Nabumetone
Severity: Moderate
Dabigatran etexilate and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone, an NSAID, can still affect platelets and gastrointestinal mucosa, so it adds to bleeding risk with dabigatran. The risk may be somewhat lower than with other NSAIDs but is not eliminated.
What this interaction means in plain words
Dabigatran etexilate and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis: NSAID platelet inhibition and mucosal injury with thrombin inhibition.
What to do
Prefer paracetamol or other alternatives. If used, keep dose and duration minimal and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Dabigatran etexilate with Nabumetone?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone, an NSAID, can still affect platelets and gastrointestinal mucosa, so it adds to bleeding risk with dabigatran. The risk may be somewhat lower than with other NSAIDs but is not eliminated.
How serious is the interaction between Dabigatran etexilate and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or other alternatives. If used, keep dose and duration minimal and monitor for bleeding.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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