Drug interactions
Dabigatran etexilate + Pegaspargase
Severity: Moderate
Dabigatran etexilate and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase lowers synthesis of coagulation factors and anticoagulant proteins, causing both bleeding and thrombotic complications. Adding dabigatran may increase bleeding risk.
What this interaction means in plain words
Dabigatran etexilate and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Pegaspargase belongs to Oncology.
Why it happens
Asparaginase-induced hypofibrinogenemia and reduced clotting factor synthesis add pharmacodynamically to anticoagulation by dabigatran.
What to do
Monitor fibrinogen, platelet count and coagulation tests and watch for bleeding. Consider holding or switching the anticoagulant if fibrinogen or platelets fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Pegaspargase?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase lowers synthesis of coagulation factors and anticoagulant proteins, causing both bleeding and thrombotic complications. Adding dabigatran may increase bleeding risk.
How serious is the interaction between Dabigatran etexilate and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fibrinogen, platelet count and coagulation tests and watch for bleeding. Consider holding or switching the anticoagulant if fibrinogen or platelets fall markedly.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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