Drug interactions
Dabigatran etexilate + Tipranavir
Severity: Major
Dabigatran etexilate and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir/ritonavir has mixed effects on P-gp and tipranavir also has antiplatelet activity, so dabigatran exposure can change and bleeding risk is increased. Dabigatran labeling advises against use with tipranavir/ritonavir in patients with renal impairment.
What this interaction means in plain words
Dabigatran etexilate and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Variable P-glycoprotein modulation by tipranavir/ritonavir combined with additive antiplatelet effect on bleeding.
What to do
Avoid the combination where possible and choose an alternative anticoagulant. If used, monitor for bleeding or thromboembolism and check renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Tipranavir?
MediHelp rates the interaction as major. Dabigatran etexilate and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir/ritonavir has mixed effects on P-gp and tipranavir also has antiplatelet activity, so dabigatran exposure can change and bleeding risk is increased. Dabigatran labeling advises against use with tipranavir/ritonavir in patients with renal impairment.
How serious is the interaction between Dabigatran etexilate and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative anticoagulant. If used, monitor for bleeding or thromboembolism and check renal function.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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