Drug interactions
Dabrafenib + Dantrolene
Severity: Moderate
Dabrafenib and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may reduce exposure to dantrolene, which is metabolized hepatically. This could weaken dantrolene's effect.
What this interaction means in plain words
Dabrafenib and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Dantrolene belongs to Musculoskeletal.
Why it happens
Dabrafenib induces CYP3A4, increasing dantrolene metabolism.
What to do
Monitor response to dantrolene and adjust the dose if effect is diminished. Review need for the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Dantrolene?
MediHelp rates the interaction as moderate. Dabrafenib and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may reduce exposure to dantrolene, which is metabolized hepatically. This could weaken dantrolene's effect.
How serious is the interaction between Dabrafenib and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to dantrolene and adjust the dose if effect is diminished. Review need for the combination.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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