Drug interactions
Dabrafenib + Ergotamine
Severity: Moderate
Dabrafenib and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower ergotamine levels, reducing migraine efficacy. Ergotamine's narrow safety margin limits compensatory dose increases.
What this interaction means in plain words
Dabrafenib and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Ergotamine belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP3A4, increasing ergotamine metabolism.
What to do
Monitor for reduced ergotamine effect and consider an alternative migraine treatment. Do not exceed labeled ergotamine doses to compensate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Ergotamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ergotamine?
MediHelp rates the interaction as moderate. Dabrafenib and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower ergotamine levels, reducing migraine efficacy. Ergotamine's narrow safety margin limits compensatory dose increases.
How serious is the interaction between Dabrafenib and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced ergotamine effect and consider an alternative migraine treatment. Do not exceed labeled ergotamine doses to compensate.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
