Drug interactions
Dabrafenib + Esomeprazole
Severity: Moderate
Dabrafenib and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Higher gastric pH may reduce dabrafenib absorption, while dabrafenib induces enzymes that can lower esomeprazole levels. Both effects could reduce the efficacy of either drug.
What this interaction means in plain words
Dabrafenib and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces dabrafenib solubility, and dabrafenib induction of CYP2C19 and CYP3A4 increases esomeprazole clearance.
What to do
Avoid unnecessary acid suppression; if a PPI is needed, monitor oncologic response and acid control, and consider an alternative regimen if either is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Esomeprazole?
MediHelp rates the interaction as moderate. Dabrafenib and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Higher gastric pH may reduce dabrafenib absorption, while dabrafenib induces enzymes that can lower esomeprazole levels. Both effects could reduce the efficacy of either drug.
How serious is the interaction between Dabrafenib and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary acid suppression; if a PPI is needed, monitor oncologic response and acid control, and consider an alternative regimen if either is inadequate.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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