Drug interactions
Dabrafenib + Estradiol
Severity: Moderate
Dabrafenib and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes and can reduce estradiol exposure, lowering the effect of hormone therapy. Hormonal contraceptives may also become unreliable.
What this interaction means in plain words
Dabrafenib and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Estradiol belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4 (and UGT enzymes), increasing estradiol clearance.
What to do
Monitor clinical response and increase the estradiol dose if needed. Recommend a non-hormonal contraceptive method during dabrafenib therapy and for a period after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Estradiol?
MediHelp rates the interaction as moderate. Dabrafenib and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and other enzymes and can reduce estradiol exposure, lowering the effect of hormone therapy. Hormonal contraceptives may also become unreliable.
How serious is the interaction between Dabrafenib and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the estradiol dose if needed. Recommend a non-hormonal contraceptive method during dabrafenib therapy and for a period after stopping.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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