Drug interactions
Dabrafenib + Everolimus
Severity: Moderate
Dabrafenib and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can reduce everolimus exposure, which may lessen efficacy or lower immunosuppression in transplant patients.
What this interaction means in plain words
Dabrafenib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Everolimus belongs to Oncology.
Why it happens
Induction of CYP3A4 increases everolimus metabolic clearance.
What to do
Monitor everolimus trough concentrations and clinical response, and increase the dose if levels are subtherapeutic. Recheck levels after dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Everolimus?
MediHelp rates the interaction as moderate. Dabrafenib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can reduce everolimus exposure, which may lessen efficacy or lower immunosuppression in transplant patients.
How serious is the interaction between Dabrafenib and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and clinical response, and increase the dose if levels are subtherapeutic. Recheck levels after dabrafenib is stopped.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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