Drug interactions
Dabrafenib + Gemfibrozil
Severity: Major
Dabrafenib and Gemfibrozil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil is a strong CYP2C8 inhibitor, and CYP2C8 is a main route of dabrafenib metabolism. Dabrafenib exposure increases, which can heighten toxicities such as pyrexia, rash and hyperglycemia.
What this interaction means in plain words
Dabrafenib and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Gemfibrozil belongs to Cardiovascular.
Why it happens
Gemfibrozil inhibits CYP2C8-mediated oxidation of dabrafenib.
What to do
Avoid the combination where possible and choose a lipid-lowering alternative such as a statin or fenofibrate. If needed, monitor closely for dabrafenib adverse effects and consider dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Gemfibrozil?
MediHelp rates the interaction as major. Dabrafenib and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil is a strong CYP2C8 inhibitor, and CYP2C8 is a main route of dabrafenib metabolism. Dabrafenib exposure increases, which can heighten toxicities such as pyrexia, rash and hyperglycemia.
How serious is the interaction between Dabrafenib and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a lipid-lowering alternative such as a statin or fenofibrate. If needed, monitor closely for dabrafenib adverse effects and consider dose reduction.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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