Drug reference
gemfibrozil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Hyperlipidemics)
Mechanism of action
Inhibits peripheral lipolysis; decreases hepatic uptake of free fatty acids, which may in turn inhibit secretion of VLDL; may increase HDL-cholesterol (mechanism unknown)
Common side effects
- Dyspepsia
- Fatigue
- Atrial fibrillation
- Abdominal pain
- Diarrhea
Known interactions (9)
- gemfibrozil + metformin-repaglinide Contraindicated
- gemfibrozil + repaglinide Contraindicated
- atorvastatin + gemfibrozil Major
- enzalutamide + gemfibrozil Major
- fluvastatin + gemfibrozil Major
- gemfibrozil + pitavastatin Major
- gemfibrozil + pravastatin Major
- gemfibrozil + rosuvastatin Major
- gemfibrozil + simvastatin Major
Related conditions
Frequently asked questions
What drug class is gemfibrozil?
gemfibrozil belongs to: Cardiovascular.
How does gemfibrozil work?
Inhibits peripheral lipolysis; decreases hepatic uptake of free fatty acids, which may in turn inhibit secretion of VLDL; may increase HDL-cholesterol (mechanism unknown)
What are the common side effects of gemfibrozil?
Dyspepsia, Fatigue, Atrial fibrillation, Abdominal pain, Diarrhea
Which drugs interact with gemfibrozil?
metformin-repaglinide, repaglinide, atorvastatin, enzalutamide, fluvastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin
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