Drug interactions
Dabrafenib + Ixazomib
Severity: Major
Dabrafenib and Ixazomib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a moderate to strong CYP3A4 inducer and may lower ixazomib concentrations. Strong CYP3A inducers markedly reduced ixazomib exposure in a pharmacokinetic study, so efficacy may be lost.
What this interaction means in plain words
Dabrafenib and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Ixazomib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing ixazomib metabolism.
What to do
Avoid coadministration. Use an alternative to dabrafenib or ixazomib if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ixazomib
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ixazomib?
MediHelp rates the interaction as major. Dabrafenib and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is a moderate to strong CYP3A4 inducer and may lower ixazomib concentrations. Strong CYP3A inducers markedly reduced ixazomib exposure in a pharmacokinetic study, so efficacy may be lost.
How serious is the interaction between Dabrafenib and Ixazomib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative to dabrafenib or ixazomib if feasible.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Ixazomib page.
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