Drug interactions
Etrasimod + Ixazomib
Severity: Major
Etrasimod and Ixazomib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and ixazomib is an immunosuppressive antineoplastic. Combined use may increase infection risk. It has not been studied.
What this interaction means in plain words
Etrasimod and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Ixazomib belongs to Oncology.
Why it happens
Additive immunosuppression from S1P receptor modulation and proteasome inhibition.
What to do
Avoid when possible. If needed, monitor for infection and lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ixazomib
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Ixazomib?
MediHelp rates the interaction as major. Etrasimod and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes and ixazomib is an immunosuppressive antineoplastic. Combined use may increase infection risk. It has not been studied.
How serious is the interaction between Etrasimod and Ixazomib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid when possible. If needed, monitor for infection and lymphocyte counts.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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