Drug interactions
Enzalutamide + Ixazomib
Severity: Major
Enzalutamide and Ixazomib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inducers substantially reduce ixazomib exposure, as shown in pharmacokinetic studies with rifampin. This can lead to loss of efficacy.
What this interaction means in plain words
Enzalutamide and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Ixazomib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing ixazomib metabolism.
What to do
Avoid coadministration with strong CYP3A inducers as per labeling. Consider an alternative to enzalutamide.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
- Ixazomib + Lumacaftor / ivacaftor Major
Frequently asked questions
Can I take Enzalutamide with Ixazomib?
MediHelp rates the interaction as major. Enzalutamide and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A inducers substantially reduce ixazomib exposure, as shown in pharmacokinetic studies with rifampin. This can lead to loss of efficacy.
How serious is the interaction between Enzalutamide and Ixazomib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration with strong CYP3A inducers as per labeling. Consider an alternative to enzalutamide.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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