Drug interactions
Carbamazepine + Ixazomib
Severity: Major
Carbamazepine and Ixazomib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine substantially reduces ixazomib exposure, which may compromise treatment of multiple myeloma.
What this interaction means in plain words
Carbamazepine and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Ixazomib belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4, increasing the metabolism of ixazomib.
What to do
Avoid concurrent use and choose a non-inducing antiseizure drug. Monitor disease response if the combination is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
- Ixazomib + Lumacaftor / ivacaftor Major
Frequently asked questions
Can I take Carbamazepine with Ixazomib?
MediHelp rates the interaction as major. Carbamazepine and Ixazomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine substantially reduces ixazomib exposure, which may compromise treatment of multiple myeloma.
How serious is the interaction between Carbamazepine and Ixazomib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-inducing antiseizure drug. Monitor disease response if the combination is unavoidable.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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