Drug interactions
Ixazomib + Lumacaftor / ivacaftor
Severity: Major
Ixazomib and Lumacaftor / ivacaftor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may substantially lower ixazomib concentrations. This may result in loss of antineoplastic efficacy.
What this interaction means in plain words
Ixazomib and Lumacaftor / ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Lumacaftor induces intestinal and hepatic CYP3A4, increasing ixazomib metabolism.
What to do
Avoid the combination and choose an alternative CYP-neutral therapy where possible. If unavoidable, monitor myeloma response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Ixazomib with Lumacaftor / ivacaftor?
MediHelp rates the interaction as major. Ixazomib and Lumacaftor / ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumacaftor is a strong CYP3A inducer and may substantially lower ixazomib concentrations. This may result in loss of antineoplastic efficacy.
How serious is the interaction between Ixazomib and Lumacaftor / ivacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative CYP-neutral therapy where possible. If unavoidable, monitor myeloma response closely.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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