Drug interactions
Dabrafenib + Methylprednisolone
Severity: Moderate
Dabrafenib and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower methylprednisolone concentrations. Reduced corticosteroid effect could lead to inadequate control of the condition being treated.
What this interaction means in plain words
Dabrafenib and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Methylprednisolone belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4, increasing the metabolism of methylprednisolone.
What to do
Monitor clinical response and increase the methylprednisolone dose if needed. Reduce the dose again if dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Methylprednisolone?
MediHelp rates the interaction as moderate. Dabrafenib and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may lower methylprednisolone concentrations. Reduced corticosteroid effect could lead to inadequate control of the condition being treated.
How serious is the interaction between Dabrafenib and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the methylprednisolone dose if needed. Reduce the dose again if dabrafenib is discontinued.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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