Drug interactions
Dabrafenib + Mirtazapine
Severity: Moderate
Dabrafenib and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower mirtazapine levels, risking loss of antidepressant efficacy. The magnitude is not well characterized for mirtazapine.
What this interaction means in plain words
Dabrafenib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP3A4, accelerating mirtazapine metabolism.
What to do
Monitor for relapse of depressive symptoms and raise the mirtazapine dose if needed. Reduce it again after dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Mirtazapine?
MediHelp rates the interaction as moderate. Dabrafenib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may lower mirtazapine levels, risking loss of antidepressant efficacy. The magnitude is not well characterized for mirtazapine.
How serious is the interaction between Dabrafenib and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for relapse of depressive symptoms and raise the mirtazapine dose if needed. Reduce it again after dabrafenib is discontinued.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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