Drug interactions
Dabrafenib + Modafinil
Severity: Moderate
Dabrafenib and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4, which contributes to modafinil clearance, so modafinil concentrations may fall. Reduced wakefulness-promoting effect may result.
What this interaction means in plain words
Dabrafenib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Dabrafenib induction of CYP3A4 increases modafinil metabolism.
What to do
Monitor efficacy of modafinil and increase the dose if needed. Reassess the dose when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Modafinil
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Modafinil?
MediHelp rates the interaction as moderate. Dabrafenib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4, which contributes to modafinil clearance, so modafinil concentrations may fall. Reduced wakefulness-promoting effect may result.
How serious is the interaction between Dabrafenib and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor efficacy of modafinil and increase the dose if needed. Reassess the dose when dabrafenib is stopped.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
