Drug interactions
Dabrafenib + Ondansetron
Severity: Minor
Dabrafenib and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes, which may lower ondansetron concentrations. Antiemetic efficacy could be reduced.
What this interaction means in plain words
Dabrafenib and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Induction of CYP3A4 by dabrafenib increases ondansetron metabolism.
What to do
Monitor for breakthrough nausea and vomiting and consider an additional or alternative antiemetic if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ondansetron?
MediHelp rates the interaction as minor. Dabrafenib and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes, which may lower ondansetron concentrations. Antiemetic efficacy could be reduced.
How serious is the interaction between Dabrafenib and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and consider an additional or alternative antiemetic if control is inadequate.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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