Drug interactions
Dabrafenib + Oxycodone
Severity: Moderate
Dabrafenib and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can reduce oxycodone concentrations, potentially causing loss of analgesic effect. Opioid withdrawal or inadequate pain control may occur, and stopping dabrafenib could lead to higher oxycodone levels.
What this interaction means in plain words
Dabrafenib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Oxycodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by dabrafenib increases oxycodone metabolism.
What to do
Monitor pain control and titrate oxycodone upward if needed. Reduce the dose and watch for sedation when dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Oxycodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Oxycodone?
MediHelp rates the interaction as moderate. Dabrafenib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can reduce oxycodone concentrations, potentially causing loss of analgesic effect. Opioid withdrawal or inadequate pain control may occur, and stopping dabrafenib could lead to higher oxycodone levels.
How serious is the interaction between Dabrafenib and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate oxycodone upward if needed. Reduce the dose and watch for sedation when dabrafenib is discontinued.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
