Drug interactions
Dabrafenib + Ranolazine
Severity: Major
Dabrafenib and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower ranolazine concentrations, reducing antianginal efficacy. Because ranolazine depends on CYP3A4 metabolism, this effect can be clinically relevant.
What this interaction means in plain words
Dabrafenib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, increasing ranolazine clearance.
What to do
Avoid the combination where possible, in line with ranolazine labeling for CYP3A inducers. If unavoidable, monitor for recurrent angina and consider an alternative antianginal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ranolazine?
MediHelp rates the interaction as major. Dabrafenib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and may lower ranolazine concentrations, reducing antianginal efficacy. Because ranolazine depends on CYP3A4 metabolism, this effect can be clinically relevant.
How serious is the interaction between Dabrafenib and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, in line with ranolazine labeling for CYP3A inducers. If unavoidable, monitor for recurrent angina and consider an alternative antianginal.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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