Drug interactions
Dabrafenib + Ruxolitinib
Severity: Moderate
Dabrafenib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce ruxolitinib concentrations. Reduced efficacy of ruxolitinib is possible.
What this interaction means in plain words
Dabrafenib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
CYP3A4 induction by dabrafenib increases ruxolitinib metabolism.
What to do
Monitor blood counts and disease response, and adjust ruxolitinib dose upward within label limits if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ruxolitinib?
MediHelp rates the interaction as moderate. Dabrafenib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may reduce ruxolitinib concentrations. Reduced efficacy of ruxolitinib is possible.
How serious is the interaction between Dabrafenib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and disease response, and adjust ruxolitinib dose upward within label limits if response is inadequate.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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