Drug interactions
Dabrafenib + Tramadol
Severity: Minor
Dabrafenib and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2B6, which may lower tramadol concentrations. This could reduce analgesia, while formation of the active metabolite via CYP2D6 is largely unaffected.
What this interaction means in plain words
Dabrafenib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by dabrafenib increases tramadol clearance.
What to do
Monitor pain control and titrate tramadol upward if analgesia is inadequate, or choose an alternative analgesic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tramadol?
MediHelp rates the interaction as minor. Dabrafenib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and CYP2B6, which may lower tramadol concentrations. This could reduce analgesia, while formation of the active metabolite via CYP2D6 is largely unaffected.
How serious is the interaction between Dabrafenib and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate tramadol upward if analgesia is inadequate, or choose an alternative analgesic.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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