Drug interactions
Dabrafenib + Trazodone
Severity: Moderate
Dabrafenib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4, the main enzyme that clears trazodone. Trazodone exposure may fall, which could reduce antidepressant or hypnotic effect.
What this interaction means in plain words
Dabrafenib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Dabrafenib induces hepatic and intestinal CYP3A4, increasing trazodone metabolism.
What to do
Monitor for loss of trazodone efficacy and increase the dose if clinically needed. Reassess the dose after dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Trazodone?
MediHelp rates the interaction as moderate. Dabrafenib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4, the main enzyme that clears trazodone. Trazodone exposure may fall, which could reduce antidepressant or hypnotic effect.
How serious is the interaction between Dabrafenib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of trazodone efficacy and increase the dose if clinically needed. Reassess the dose after dabrafenib is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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