Drug interactions
Dabrafenib + Vortioxetine
Severity: Moderate
Dabrafenib and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C9 and may lower vortioxetine concentrations, reducing antidepressant effect. Vortioxetine labeling advises considering a dose increase with prolonged use of broad CYP inducers.
What this interaction means in plain words
Dabrafenib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP enzymes, mainly CYP3A4, increasing the metabolism of vortioxetine.
What to do
Monitor for loss of efficacy and consider increasing vortioxetine within the labeled maximum, with no more than three times the original dose. Return to the original dose within 14 days of stopping dabrafenib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Vortioxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Vortioxetine?
MediHelp rates the interaction as moderate. Dabrafenib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C9 and may lower vortioxetine concentrations, reducing antidepressant effect. Vortioxetine labeling advises considering a dose increase with prolonged use of broad CYP inducers.
How serious is the interaction between Dabrafenib and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider increasing vortioxetine within the labeled maximum, with no more than three times the original dose. Return to the original dose within 14 days of stopping dabrafenib.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
