Drug interactions
Dacarbazine + Rucaparib
Severity: Minor
Dacarbazine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2, which contributes to dacarbazine metabolism. Exposure to dacarbazine and its active metabolite may therefore change, though the clinical significance is uncertain.
What this interaction means in plain words
Dacarbazine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacarbazine belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2-mediated metabolism of dacarbazine.
What to do
Monitor blood counts and hepatic function and for signs of dacarbazine toxicity or reduced efficacy. Adjust the dacarbazine dose if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dacarbazine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Dacarbazine with Rucaparib?
MediHelp rates the interaction as minor. Dacarbazine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2, which contributes to dacarbazine metabolism. Exposure to dacarbazine and its active metabolite may therefore change, though the clinical significance is uncertain.
How serious is the interaction between Dacarbazine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and hepatic function and for signs of dacarbazine toxicity or reduced efficacy. Adjust the dacarbazine dose if clinically indicated.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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