Drug interactions
Dacomitinib + Paroxetine
Severity: Moderate
Dacomitinib and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor, and paroxetine is both a CYP2D6 substrate and a potent inhibitor. Paroxetine exposure may rise, though its own metabolism is partly self-inhibited, so the added effect is usually modest. Increased paroxetine adverse effects such as nausea, sedation and anticholinergic effects may occur.
What this interaction means in plain words
Dacomitinib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Paroxetine belongs to Central Nervous System.
Why it happens
Dacomitinib inhibits CYP2D6, reducing paroxetine metabolism.
What to do
Monitor for paroxetine adverse effects and reduce the dose if they occur. Consider an antidepressant not dependent on CYP2D6 if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Paroxetine?
MediHelp rates the interaction as moderate. Dacomitinib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor, and paroxetine is both a CYP2D6 substrate and a potent inhibitor. Paroxetine exposure may rise, though its own metabolism is partly self-inhibited, so the added effect is usually modest. Increased paroxetine adverse effects such as nausea, sedation and anticholinergic effects may occur.
How serious is the interaction between Dacomitinib and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paroxetine adverse effects and reduce the dose if they occur. Consider an antidepressant not dependent on CYP2D6 if tolerability is poor.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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