Drug interactions
Dacomitinib + Timolol
Severity: Moderate
Dacomitinib and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and can markedly raise exposure to timolol, which is partly metabolised by CYP2D6. This can increase beta-blocker effects such as bradycardia and hypotension. Even ophthalmic timolol can have increased systemic effects.
What this interaction means in plain words
Dacomitinib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Timolol belongs to Cardiovascular.
Why it happens
Dacomitinib inhibits CYP2D6, reducing timolol clearance.
What to do
Monitor heart rate and blood pressure, and reduce the timolol dose if bradycardia or hypotension occurs. Consider an alternative ocular agent in patients with cardiac or respiratory disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Timolol?
MediHelp rates the interaction as moderate. Dacomitinib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and can markedly raise exposure to timolol, which is partly metabolised by CYP2D6. This can increase beta-blocker effects such as bradycardia and hypotension. Even ophthalmic timolol can have increased systemic effects.
How serious is the interaction between Dacomitinib and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce the timolol dose if bradycardia or hypotension occurs. Consider an alternative ocular agent in patients with cardiac or respiratory disease.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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