Drug interactions
Dalteparin + Deflazacort
Severity: Moderate
Dalteparin and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids can increase the risk of gastrointestinal ulceration and bleeding, which matters in anticoagulated patients. Effects on coagulation are inconsistent and the INR is not a useful monitor for dalteparin.
What this interaction means in plain words
Dalteparin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Corticosteroid-related mucosal injury and vascular fragility add to heparin-induced bleeding risk.
What to do
Monitor for signs of bleeding, particularly GI, and consider gastroprotection with prolonged steroid use. Check haemoglobin if therapy continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Dalteparin with Deflazacort?
MediHelp rates the interaction as moderate. Dalteparin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids can increase the risk of gastrointestinal ulceration and bleeding, which matters in anticoagulated patients. Effects on coagulation are inconsistent and the INR is not a useful monitor for dalteparin.
How serious is the interaction between Dalteparin and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly GI, and consider gastroprotection with prolonged steroid use. Check haemoglobin if therapy continues.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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