Drug interactions
Dalteparin + Dexamethasone
Severity: Moderate
Dalteparin and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can cause GI ulceration and impair vascular integrity, raising bleeding risk in patients on dalteparin. The size of the effect varies with dose and duration of steroid use.
What this interaction means in plain words
Dalteparin and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Dexamethasone belongs to Endocrine.
Why it happens
Corticosteroid-related mucosal injury and vascular fragility add to heparin-induced bleeding risk.
What to do
Monitor for bleeding, especially GI bleeding, and consider a proton pump inhibitor with higher doses or longer courses. Check haemoglobin if therapy continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dalteparin with Dexamethasone?
MediHelp rates the interaction as moderate. Dalteparin and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone can cause GI ulceration and impair vascular integrity, raising bleeding risk in patients on dalteparin. The size of the effect varies with dose and duration of steroid use.
How serious is the interaction between Dalteparin and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, especially GI bleeding, and consider a proton pump inhibitor with higher doses or longer courses. Check haemoglobin if therapy continues.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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