Drug interactions
Dalteparin + Enoxaparin
Severity: Major
Dalteparin and Enoxaparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two low molecular weight heparins have the same mechanism, so combining them provides no benefit and increases bleeding risk. This is therapeutic duplication.
What this interaction means in plain words
Dalteparin and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Duplicate antithrombin-mediated anti-Xa and anti-IIa activity.
What to do
Do not give together; use a single LMWH and, when switching, start the new one when the next dose is due. Monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Enoxaparin?
MediHelp rates the interaction as major. Dalteparin and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two low molecular weight heparins have the same mechanism, so combining them provides no benefit and increases bleeding risk. This is therapeutic duplication.
How serious is the interaction between Dalteparin and Enoxaparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together; use a single LMWH and, when switching, start the new one when the next dose is due. Monitor for bleeding.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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