Drug interactions
Dalteparin + Fosinopril
Severity: Moderate
Dalteparin and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone secretion and raise serum potassium. With an ACE inhibitor the risk of hyperkalemia is increased, especially with renal impairment or diabetes.
What this interaction means in plain words
Dalteparin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Fosinopril belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to the reduced aldosterone effect from ACE inhibition.
What to do
Monitor serum potassium, particularly with prolonged dalteparin use or reduced renal function. Treat hyperkalemia and reassess therapy if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Fosinopril?
MediHelp rates the interaction as moderate. Dalteparin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone secretion and raise serum potassium. With an ACE inhibitor the risk of hyperkalemia is increased, especially with renal impairment or diabetes.
How serious is the interaction between Dalteparin and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with prolonged dalteparin use or reduced renal function. Treat hyperkalemia and reassess therapy if it develops.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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