Drug interactions
Dalteparin + Hydrochlorothiazide-valsartan
Severity: Moderate
Dalteparin and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can reduce aldosterone production and, together with an angiotensin receptor blocker, may raise serum potassium. The risk is greater in renal impairment, diabetes or prolonged therapy. The thiazide component partly offsets this effect.
What this interaction means in plain words
Dalteparin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Heparin suppresses adrenal aldosterone synthesis, adding to the reduced aldosterone effect from angiotensin receptor blockade and causing potassium retention.
What to do
Monitor serum potassium and renal function, especially if dalteparin is continued beyond a few days or in patients with renal impairment. Treat hyperkalemia if it develops and review the need for either agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Dalteparin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can reduce aldosterone production and, together with an angiotensin receptor blocker, may raise serum potassium. The risk is greater in renal impairment, diabetes or prolonged therapy. The thiazide component partly offsets this effect.
How serious is the interaction between Dalteparin and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially if dalteparin is continued beyond a few days or in patients with renal impairment. Treat hyperkalemia if it develops and review the need for either agent.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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