Drug interactions
Dalteparin + Ibrutinib
Severity: Major
Dalteparin and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is linked to bleeding, including major haemorrhage. Anticoagulation with dalteparin adds to this risk.
What this interaction means in plain words
Dalteparin and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Ibrutinib inhibits BTK-dependent platelet signalling, adding to dalteparin anticoagulation.
What to do
Monitor closely for bleeding and check platelet counts. Consider holding ibrutinib around procedures and weigh the need for full-dose anticoagulation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dalteparin and Ibrutinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Dalteparin with Ibrutinib?
MediHelp rates the interaction as major. Dalteparin and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib impairs platelet function and is linked to bleeding, including major haemorrhage. Anticoagulation with dalteparin adds to this risk.
How serious is the interaction between Dalteparin and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and check platelet counts. Consider holding ibrutinib around procedures and weigh the need for full-dose anticoagulation.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
